New trends in the preparation and use of monoliths

Speaker: Dr. Frantisek Svec
Staff Scientist and Facility Director of the Organic and Macromolecular Synthesis Facility at the Molecular Foundry User Facility at the Lawrence Berkeley National Laboratory, Berkeley, CA

Title: New trends in the preparation and use of monoliths

Date/time/location: October 31 /4:30-5:30 pm / Gato Gallery

The modern monolithic columns emerged more than two decades ago. While the early polymer-based monoliths were used for the rapid separations of proteins, current literature describes a number of different applications in addition to typical chromatography demonstrating versatility of the monoliths. For example, monolithic columns prepared using hypercrosslinking possess a large surface area in numerous mesopores and enable efficient rapid separation of small molecules. New chemistries have been developed to afford monolithic columns for the separation in various modes. Modification of pore surface with nanoparticles is another recent trend that extends applications of monoliths in the arena of highly selective fishing out systems. Thin monolithic layers are also gaining more attention since they enable efficient separations of proteins combined with mass spectrometry using very simple means. Another new application is seen in the use of monolithic capillaries in the very fast gas chromatography. Monoliths also serve as supports for immobilization of enzymes to form very active enzymatic reactors.


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