Xiao Tang Hu, Ph.D.
Hunan Assistant Professor of Biology
Xiao Tang Hu, Ph.D. (Hunan Medical University, China) had his postdoctoral training at the Edinburgh University in UK and the University of Alabama at Birmingham (UAB). He had a research faculty position at H. Lee Moffitt Cancer Center and the University of South Florida before he joined Barry.
BIO-330, Cell Biology
BIO-330L, Cell Biology Lab
My research interest is “Cell Signaling and Cancer”: (1) I’m studying the molecular mechanisms that are responsible for cell cycle control and growth factor (with an emphasis on TGFbeta)-mediated growth inhibition in human myeloid leukemia cells, which involve in several cell cycle regulatory molecules and tumor repressor genes; (2) I ‘m studying the molecular events in cytokine/drug (with an emphasis on tumor necrosis factor)-induced apoptosis.
Selected Peer-Reviewed Publications
1. Hu X. Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation. Cytokine. 2003, 21:286-94.
2. Hu X, Bryington M, Fisher AB, Liang X, Zhang X, Cui D, Datta I, Zuckerman KS. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis actor-induced cell cycle arrest. J Biol Chem. 2002, 277:16528-37.
3. Hu X, Zhang X, Zhong Q, Fisher AB, Bryington M, Zuckerman KS. Differential effects of transforming growth factor on cell cycle regulatory molecules in human myeloid leukemia cells. Oncogene. 2001, 20:6840-50.
4. Hu X, Janssen WE, Moscinski LC, Bryington M, Dangsupa A, Rezai-Zadeh N, Babbin BA, Zuckerman KS. An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism. Cancer Res. 2001, 61:6290-6.
5. Hu X, Zuckerman KS. Transforming growth factor: signal transduction pathways, cell cycle mediation, and effects on hematopoiesis. J Hematother Stem Cell Res. 2001, 10:67-74.
6. Hu X, DW Cress, Q Zhong, and KS Zuckerman. (2000) Transforming growth factor-beta inhibits the phosphorylation of pRb at multiple serine/threonine sites and differentially regulates the formation of pRb family-E2F complexes in human myeloid leukemia cells. Biochem Biophys Res Commun 276: 930-939.
7. Hu X, Zuckerman KS. Cell cycle and transcriptional control of human myeloid leukemic cells by transforming growth factor beta. Leuk Lymphoma. 2000, 38:235-46.
8. Hu X, Moscinski LC, Valkov NI, Fisher AB, Hill BJ, Zuckerman KS. Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line. Cell Growth Differ. 2000, 11:191-200.
9. Hu X, Tang M, Fisher AB, Olashaw N, Zuckerman KS. TNF-alpha-induced growth suppression of CD34+ myeloid leukemic cell lines signals through TNF receptor type I and is associated with NF-kappa B activation. J Immunol. 1999, 163:3106-15.
10. Hu X, Moscinski LC, Zuckerman KS. Transforming growth factor beta inhibits growth of more differentiated myeloid leukemia cells and retinoblastoma protein phosphorylation at serine 795. Exp Hematol. 1999, 27:605-14.
11. Hu X, Moscinski LC, Hill BJ, Chen Q, Wu J, Fisher AB, Zuckerman KS. Characterization of a unique factor-independent variant derived from human factor-dependent TF-1 cells: a transformed event. Leuk Res. 1998, 22:817-26.
12. Hu X, Zuckerman KS. Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein.
Am J Hematol. 1998, 58:145-7.
13. Hu X and Zuckerman KS (1996) Removing monolayer cells from culture dishes by incubation with EDTA in studies of cell surface receptors. BioTechniques 21: 784-786.
14. Hu X, Zuckerman KS. (1995): Isolation by RT-PCR and analysis of full-length cDNA clones from human blood mononuclear cells encoding the common beta-subunit of GM-CSF, IL-3 and IL-5 receptors. Focus 17 (1), 21-24.
15. Unlap T, Hu X (1995): Direct identification of recombinant clones in Escherichia coli utilizing supercoiled DNA. BioTechniques 18 (4) 590-594.
16. Hu X, Emanuel PD, Zuckerman KS. (1994): Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha-subunit of the granulocyte-macrophage colony-stimulating factor receptor. Biochem. Biophys. Acta 1223 306-308.
17. Hu X, Xu Y, Zhou Y (1990) The Effect of Carbamylcholine on CFU-S differentiation. Inter J Cell Cloning 8:377-384
Zuckerman KS, Emanuel PD, Hu X (1992): Molecular Pathophysiology of Juvenile Chronic Myeloid Leukemia. In: Abraham NG, Marks PA, Konwalinka G, Sachs L, Tavassoli M(eds), Molecular Biology of Hematopoiesis 1992, Intercept Scientific, Medical, & Technical Publications, Ltd, Andover, Hampshire, England.
1 2005 MARC travel award from FASEB Career Resources/MARC program/NIH
2 1989 Royal Fellowship from the Royal Society of Britain, London, The United Kingdom (certification available upon request).
3 1988 Boehringer Inhelheim Funds from Boehringer Inhelheim Corporation, West Germany (certification available upon request).
4 1988 Re. Robert White Fellowship from British Society for Immunology, London, the United Kingdom.
1 American Society for Cell Biology (Active)
2 American Association for the Advancement of Science (Active)
3 International Society of Experimental Hematology (Active)
4 International Society of Cytokine (2002-2003)
5 Membership in Residence of H. Lee Moffitt Cancer Center and Research Institute (1995-2003)
6 The American Society of Hematology (1994-1997)
7 The British Society for Immunology (1990-1991)