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The Department of Physical Sciences invites the Barry Community to a lecture by Fulbright Scholar Ondrej Sedlacek, Ph.D., entitled, “Structural and chemical aspects of HPMA copolymers as drug carriers.”
Date: Monday, Feb. 11, 2013
Time: 1 p.m.
Location: Wiegend Annex 103
About the lecture:
Targeted delivery and controlled release using polymer carriers became widely studied approach to circumvent side effects of anticancer drugs. The drug is attached to a polymer carrier by biodegradable linker. This biologically inactive prodrug conjugate is delivered to the cancer tissue, where it is concentrated by, e.g., Enhanced Permeation and Retention (EPR) accumulation or ligand-based targeting. In tumor tissue the conjugate releases its cargo in biologically active form. In this talk, I will delineate the recent development of N-(2-hydroxypropyl)methacrylamide (HPMA) based polymer conjugates with anti cancer drug Doxorubicin as a promising candidates for advanced therapy of solid tumors.