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Alzheimer's
Disease
Dr.
George Fisher, Professor of Chemistry
gfisher@mail.barry.edu
| Dr.
George Fisher |
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| Mara
Tsesarskaja |
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Dr.
Fisher's research concerns the involvement of altered amino acids in dysfunctional systems
such as Alzheimer's diseased brain and osteoarthritic cartilage. Specifically,
he is investigating the role of D-aspartate (D-Asp) in these dysfunctions
compared
to normal conditions. He is also studying the presence of N-methyl-D-aspartate
as a neurotransmitter and its synthesis from D-Asp. He is also investigating
the formation of D-Asp from normal L-Asp in heat-processed foods, such
as milks and infant formulae.
Dr. Fisher's laboratory consists of a research associate, Mara Tsesarskaja, and two student technicians.
More
Recent Publications:
- Antimo D’Aniello, Antonella De Simone, Patrizia Spinelli, Salvatore D’Aniello, Margherita Branno, Francesco Aniello, Jeannette Rios, Mara Tsesarskaja, and George Fisher. 2001. A specific enzymatic high-performance liquid chromatography method to determine N-methyl-D-aspartic acid in biological tissues. Analytical Biochemistry 308:42-51
- J.M. Lee, L. Petrucelli, G. Fisher, S. Ramdath, J. Castillo, M.M. Di Fiore, A. D’Aniello. 2002. Evidence for D-aspartyl-beta-amyloid secretase activity in human brain. J. Neuropathol. Exp. Neurol. 61(2):125-131
- Antimo D’Aniello, Patrizia Spinelli, Antonietta De Simone, Salvatore D’Aniello, Margherita Branno, Francesco Aniello, George H. Fisher, Maria M. Di Fiore, Rakesh K. Rastogi. 2003. Occurrence and neuroendocrine role of D-aspartic acid and N-methyl-D-aspartic acid in Ciona intestinalis. FEBS Letters 552:193-198
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