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Sanjay Sesodia, PhD

Professor and Chair of Basic Medical Sciences

Educational Background

  • Associate Professor, School of Graduate Medical Sciences, Barry University, Miami Shores, FL (2004 - 2009)
  • Professor, School of Podiatric Medicine, Barry University, Miami Shores, FL (2009 - Present)
  • PhD in Medicine; University of Newcastle-upon-Tyne, England.
  • MS in Experimental Histopathology/Clinical Pharmacology (Toxicology); Royal
  • Postgraduate Medical School (University of London), England.
  • BSc Physiology/Zoology (Joint Honours). University of Newcastle-upon-Tyne, England.

Prior Teaching Experience

  • Assistant Professor, School of Graduate Medical Sciences, Barry University, Miami Shores, FL (1996-2003).
  • Laboratory Instructor, School of Podiatric Medicine, Barry University, Miami Shores, FL (1995-1996).
  • Visiting Professor in Histology. Department of Anatomical Sciences, St. George's University School of Medicine, Grenada, West Indies (1994)
  • Lecturer in Muscle Pathophysiology for Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, U.S.A. (1992-1994).
  • Research Fellow; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, U.S.A. (1988 -1994)

Awards

  • MDA Post-doctoral Fellowship, Pasteur Institute, Paris, France (1986 – 1987)

Professional Societies

  • Section Chair, Medical Sciences, Florida Academy of Sciences (2007 - Present).
  • Chair, Awards Committee of Florida Academy of Sciences (2003 - 2007).
  • Councilor-at-Large, Florida Academy of Sciences (2003 - 2007).
  • American Physiological Society (2002 - Present).
  • Society for Neuroscience (1989 - Present).

Honor Societies

  • Sigma Xi (1998 - Present)
  • President, Barry University Chapter of Sigma Xi (2005 - 2006).

Research Interests

  • Differential response of skeletal muscle fiber types to denervation
    This research focuses on the premise that the different fiber types found in muscle are differentially susceptible to the loss of nerve input. Furthermore, it seeks to elucidate whether the same fiber types in different muscles respond similarly to denervation. We use immuno-histochemical and image analytical methods to qualitatively and quantitatively determine the response of skeletal muscle fibers to denervation.
  • The effects of reinnervation on regenerating mammalian skeletal muscle
    This project focuses on the role of innervation on skeletal muscle regenerating after a necrotizing injury. Earlier experiments on the slow twitch soleus muscle indicated a great reliance on innervation for full recovery. The response of fast twitch muscles in not completely known. We are interested in examining the fast muscle regenerative response using immuno-biochemical techniques to determine the fiber types, fiber proportions and fiber size after regeneration to elucidate the role of innervation on fast skeletal muscle recovery.

Recent Books / Notes, Published Papers, and Presentations

Publications (All Peer Reviewed)

  • Sesodia S, Molnar (2012) Effect of Technology on Student Class Performance and Class Absence. JAPMA 102(6) 471-476
  • Sesodia S, Shaw G, Molnar, D (2012) Can we predict 4 - year graduation in Podiatric Medical School using admission data? JAPMA 102(6) 463-470
  • Grumbles RM, Sesodia, S, Wood PM, Thomas CK (2009) Neurotrophic factors improve motoneuron survival and function of muscle reinnervation by embryonic neurons. J. Neuropathol. Exp. Neurol. 68(7); 736-746.
  • Grumbles RK, Casella GTB, Rudinsky MJ, Wood PM, Sesodia S, Bent M, Thomas CK (2007) Long-term delivery of FGF-6 changes the fiber type and fatigability of muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. J. Neurosci. Res. 85(9); 1933 - 1942.
  • Callister RJ, Sesodia S, Enoka RM, Nemeth PM, Robinson GA, Reinking RM, Stuart DG (2004) Fatigue of rat hindlimb motor units: biochemical-physiological associations. Muscle Nerve 30(6):714-726.
  • Thomas CK, Sesodia S, Erb DE, Grumbles RM (2003) Properties of medial gastrocnemius motor units and muscle fibers reinnervated by embryonic ventral spinal cord cells. Exp. Neurol. 180:25-31.
  • Sesodia S, Choksi RM and Nemeth PM (1994) Nerve-dependent recovery of metabolic pathways in regenerating soleus muscles. J. Muscle Res. Cell Motil. 15:573-581.
  • Zurlo F, Nemeth PM, Choksi RM, Sesodia S and Ravussin E (1994) Whole body energy metabolism and skeletal muscle biochemical characteristics. Metabolism: Clinical & Experimental. 43:481-486.
  • Sesodia S and Cullen MJ (1991) The effect of denervation on the morphology of regenerating soleus muscles of the rat. Acta Neuropathologica 82: 21-32.
  • Whalen RG, Harris JB, Butler-Browne GS and Sesodia S (1990) Expression of myosin isoforms during Notexin-induced regeneration of rat soleus muscles. Dev. Biol. 141: 24-40.
  • Sesodia S (1986) The effect of denervation and reinnervation on the regeneration of mammalian skeletal muscle. PhD Thesis, University of Newcastle-upon-Tyne, England.

Publications under Review

  • Grumbles RM, Sesodia S, Wood PM, Thomas CK (2008) Neurotrophic factors improve motoneuron survival and function of muscle reinnervation by embryonic neurons. Exp Neurol.

Oral Presentations

  • Florida Acad Sci 70th Ann. Mtg. (2006) Denervation effects on skeletal muscle fiber types.
  • Florida Acad Sci 68th Ann. Mtg. (2004) Differential behavior of fiber types in fast and slow twitch muscles following denervation.
  • Florida Acad Sci 66th Ann. Mtg. (2002) Muscle properties after reinnervation by embryonic nerve cells.
  • Soc Neurosci 31st Ann. Mtg. (2001) Adult rat muscle reinnervation by embryonic ventral spinal cord cells.
  • Florida Acad Sci. 64th Ann. Mtg. (2000) Does the analgesic Torbugesic affect skeletal muscle regeneration in rats?
  • Florida Acad Sci. 64th Ann. Mtg. (2000) Muscle fiber properties following reinnervation by embryonic spinal cord cells.
  • Florida Acad. Sci. 63rd Ann. Mtg. (1999) How diverse are our medical schools?
  • Soc. For Neurosci., 29th Ann. Mtg. (1999) Motor unit and muscle fiber characteristics after reinnervation by E14-15 ventral spinal cord cells.

Abstracts

  • Alkhenaizi K, Sesodia S (2008) The expression of oxidative and glycolytic capacities after skeletal muscle denervation. Florida Acad Sci 72nd Ann Mtg. Abs.
  • Ducellari B, Sesodia S (2006) Denervation effects on skeletal muscle fiber types. Florida Acad Sci 70th Ann Mtg. Abs.
  • Grumbles RM, Bent M, Wood PM, Almeida V, Vandevar M, Sesodia S, Thomas CK (2005) Differences in muscle reinnervation following transplantation of E12 versus E14 spinal cord cells into adult rat peripheral nerve. Soc Neurosci 35th Ann Meeting Abs.
  • Sesodia S, Richardson SD (2004) Differential behavior of fiber types in fast and slow twitch muscles following denervation. Florida Acad Sci 68th Ann Mtg. Abs.
  • Thomas CK, Rudinsky MJ, Sesodia S, Casella GTB, Bent M, Grumbles RM (2003) Long term delivery of trophic factors to muscle reinnervated from embryonic neurons transplanted into adult rat peripheral nerve. Soc Neurosci 33rd Ann Meeting Abs.
  • Richardson SD, Sesodia S (2003) Differential muscle fiber type atrophy after denervation. Florida Acad Sci 67th Ann Mtg. Abs.
  • Grumbles RM, Sesodia S, Rudinsky MJ, Thomas, CK (2003) Neurotrophic factors promote muscle reinnervation from embryonic neurons transplanted into adult tibial nerve. 6th International Brain Research Organization (IBRO) World Congress of Neuroscience. Abs.
  • Sesodia S, Grumbles RM, Bennett HJ, Rudinsky M, Thomas CK (2002) Muscle properties after reinnervation by embryonic nerve cells. Florida Acad Sci 66th Ann Mtg. Abs.
  • Thomas CK, Grumbles RM, Rudinsky M, Sesodia S, Gomez A, Bennett HJ, Wood P (2001) Adult rat muscle reinnervation by embryonic ventral spinal cord cells. Soc Neurosci 31st Ann. Meeting 27Abs.
  • Mirabal R, Sesodia S, Hays E (2000) Does the analgesic Torbugesic affect skeletal muscle regeneration in rats? Florida Acad Sci. 64th Ann. Mtg. 53 Abs.
  • Sesodia S, Grumbles RM, Thomas CK (2000) Muscle fiber properties following reinnervation by embryonic spinal cord cells. Florida Acad Sci. 64th Ann. Mtg., 53 Abs.
  • Sesodia S (1999) How diverse are our medical schools? Florida Acad. Sci. 63nd Ann. Mtg., 42 Abs.
  • Sesodia S, Grumbles RM, Erb DE, Thomas CK (1999) Motor unit and muscle fiber characteristics after reinnervation by E14-15 ventral spinal cord cells. Soc. For Neurosci., 29th Ann. Meeting, 1149 Abs.

Thesis Advising

  • Thesis Advisor to Sumera Ackbarali, Changes in fiber size and fiber type proportions in the extensor digitorum longs (EDL) and soles (SOL) muscles of the rat after reinnervation following sciatic nerve crush.
  • 2008
    Thesis Advisor to Sumera Ackbarali, Research beginning in Fall 2008
  • 2007 - Present
    Thesis Advisor to Kadhem Alkhenaizi, Immunohistochemical response of fiber types in different skeletal muscle after denervation
  • 2006 - Present
    Thesis Advisory Committee for Shakira Henderson, Is the core protein the sole epitope recognized in the immunohistochemical diagnosis of extramammary Paget's Disease.
  • 2004 - 2005
    Thesis Advisory Committee for Audrea Vaughan, Incorporation of Zirconyl Hematoxylin into the traditional Periodic Acid Schiff procedure to identify both neutral and acidic mucopolysaccharides.
  • 2002 - 2003
    Thesis Advisory Committee for Jeanette McNulty, The application of Zirconyl Hematoxylin to the diagnosis of Barrett's esophagus.

Additional Professional Activities

  • SPM representative on the American Association of Colleges of Podiatric Medicine Council of Faculties (2012 - Present)
  • SPM representative on the Curriculum Project for the American Association of Colleges of Podiatric Medicine Council of Faculties (2009 - Present)
  • Question writer for the Physiology section of Part 1 National Board of Podiatric Medicine Examiners exam (Basic Sciences) (1997 - Present).
  • Textbook Review for Content Connections. 2008.

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