Fulbright Scholar presents lecture "Structural and chemical aspects of HPMA copolymers as drug carriers"

Fulbright Scholar presents lecture

On February 11, 2013, the Department of Physical Sciences invited the Barry Community to a lecture by Fulbright Scholar Ondrej Sedlacek, PhD, entitled “Structural and Chemical Aspects of HPMA Copolymers as Drug Carriers.”

About the lecture:
Targeted delivery and controlled release using polymer carriers became a widely studied approach to circumvent side effects of anti-cancer drugs. The drug is attached to a polymer carrier by biodegradable linker. This biologically inactive prodrug conjugate is delivered to the cancer tissue, where it is concentrated by e.g., Enhanced Permeation and Retention (EPR) accumulation or ligand-based targeting. In tumor tissue, the conjugate releases its cargo in biologically active form. In this talk, I will delineate the recent development of N-(2-hydroxypropyl) methacrylamide (HPMA)-based polymer conjugates with anti-cancer drug Doxorubicin as a promising candidate for advanced therapy of solid tumors.